How to Check Your MTHFR and COMT Status Using Your Own Genetic Data

Where to go to browse your DNA in 23 and Me

This page offers a simple guide to help you understand specific genetic markers using data from your genetic test, like one from 23andMe or another service that lets you download raw data. While 23andMe provides its own health reports, they may not be detailed enough for certain genetic conditions. This guide is especially for those who want a deeper look into their genes but find standard reports insufficient.

If you've already taken a genetic test, I’ll show you how to access your raw data to find valuable information for making informed health decisions.

A Note on Privacy

Before submitting DNA to any company, consider the potential long-term impacts of giving a company your DNA. For those who already have a test, I’ll point out a few useful tools to make the most of your results.


Key Genes to Check

Genes are often identified by names like “rs1801133,” which may look technical but are simply labels. Once you know which ones to search for, it’s easy to access information that may be relevant to your health. This guide focuses on a few important genes.

Genes Related to Methylation

  • rs1801133
    Known as the MTHFR C677T SNP, this gene variant impacts folate metabolism.
    • (C;C) - Typical type.
    • (C;T) - About 35% lower methylation.
    • (T;T) - Roughly 70% lower methylation.
  • rs1801131
    Also called A1298C, this gene also influences methylation.
    • (A;A) - Typical type.
    • (A;C) - About 10% lower methylation.
    • (C;C) - Approximately 40-50% lower methylation.
  • rs4680
    Known as the Val158Met gene, it affects COMT enzyme activity, which helps break down neurotransmitters like dopamine and epinephrine.
    • (G;G) - Higher COMT activity, commonly called the "warrior" type, which may support faster stress recovery.
    • (A;G) - Intermediate type.
    • (A;A) - Lower COMT activity, sometimes referred to as the "worrier" type, associated with slower detox, increased estrogen, and reduced glutathione levels.

Identifying both MTHFR and COMT status is often helpful. People with reduced COMT activity may be more sensitive to folate supplements, as folate can increase neurotransmitter levels. If both MTHFR and COMT are slow, it’s usually best to address COMT first.


Accessing Your Genetics Data on 23andMe

If you’ve used 23andMe, here’s how to view your specific genes:

  1. Click on your profile in the top-right corner and select Resources from the dropdown menu.
  2. Choose Browse Raw Genotyping Data on the next page.
  3. Type the gene names (e.g., rs1801133, rs1801131, and rs4680) in the search box to check your methylation and COMT status.

Where to go to browse your DNA in 23 and Me
Typing in specific genes in 23 & Me

Using Promethease: A Simple Tool for DNA Browsing

Promethease is a useful $12 tool that lets you search your DNA for specific genes or explore genetic markers related to various health categories. At first glance it looks complicated. But it's very easy to use. Allows users to search for specific genes, or search verious health categories.

Using Prometheus To Search Through Your DNA

This guide should help you start using your genetic data in more meaningful ways.

Food Intolerance vs Food Allergy

Food Allergy Testing

The term “allergy” is often misleading. A lay person usually thinks of an allergy as an abnormal response to a food or substance that is well tolerated by most people. The medical definition, is an immune system response mediated by immunoglobulins.

Therefore, if you are having an adverse reaction to a food, for any reason other than immunoglobulins, it is not an “allergy.”

IgE Allergies

Usually allergists have looked for an immediate reaction to an allergen, such as tongue swelling, hives, or itching after eating a specific food. These symptoms indicate an IgE mediated immunoglobulin reaction.

Allergists typically test for IgE allergies with skin prick tests. Sometimes they run blood tests. These methods are excellent ways to uncover IgE mediated allergic responses. Unfortunately there are many other ways an offending food may cause symptoms. Nonetheless, for decades, allergists have been telling patients they are not allergic because they don’t have an IgE reaction against certain foods.

This is misleading. What patients want to know is not if they have an IgE mediated immune system response. They want to know what foods they are reacting to.

IgG Allergies

In holistic health, practitioners are taught that such tests miss many allergies. We are trained to look for delayed allergic reactions, such as eating an offending food followed by a headache the next day. These delayed food allergies are IgG mediated immunoglobulin reactions.

One of the most popular ways holistic practitioners test patients for food allergies is with blood tests against IgG antibodies. At times, these tests do help. But they are only testing for one type of food reaction. It is not uncommon for patients to spend hundreds of dollars on such food allergy panels just to see:

  • Almost no foods come up positive, which doesn’t help.
  • Conversely, it seems that half the panel comes up positive, which demonstrates a “leaky gut.” This however does not indicate which are the primary foods to avoid.
  • The foods they most commonly eat are positive, which is caused by repeated exposure of the immune system to that food. This thought, does not indicate if this food is the primary problem.

Although these tests can be useful in some cases, more often than not they don’t show anything significantly new, or particularly helpful.

The one exception I have seen to this is the client who has been eating a lot of gluten or dairy and doesn’t believe it is a problem. Blood tests for food allergies are a good way to prove to certain patients that they must avoid their favorite foods.

The Problem With Food Allergy Testing

Food allergies are only type of adverse reaction someone may be having against a particular food. What you need to know is not what foods allergies you have. Rather its what foods you are reacting to, regardless of underlining mechanism.

A food intolerance is a less specific terms which indicates that a food is adversely effecting health, regardless of the underlining mechanism.

Causes of food intolerances include:

  • Hypoglycemic reactions, usually to sugars and other carbohydrates.
  • Histamine reactions.
  • Deficiency in enzymes needed to digest particular foods, such as lactose intolerance, frutose intolerance and sensitivity to dietary amines.
  • Reaction to lectins, such as wheat lectins contributing to rheumatoid arthritis.
  • Neurotoxic substances such as glutamate.
  • Salicylate reactions.
  • Any other adverse reaction an individual may have to a particular food that is not currently known.

So, we can see that food allergy tests only look for one of many adverse food reactions someone may have.

A lab test may be technically right that you don’t have an “allergy” to a specific food, but at the same time it could totally miss another reason why you still have a lack of tolerance against the same food.

As far as skin prick tests, or IgE blood tests, I recommend those be used for seasonal allergies. If an IgE reaction is found for a food, then avoid that food. This is the best way to test for immediate IgE food reactions. But you can’t say a food is safe to eat, just because you don’t have an IgE reaction!

Allergy Elimination Diets

Allergy elimination diets are often taught as the best way to uncover food reactions. To do an allergy elimination diet, the patient eats a diet consisting of typically only non allergenic foods for a month or two. Then one by one, foods are reintroduced. Each day the patient charts off any symptoms they may have to uncover reactions.

This method is not practical for the real world because:

  • It can take months to properly do this.
  • Through experience I discovered that virtually no one complies with doing a proper allergy elimination / reintroduction protocol.
  • There many be typically non-allergenic foods the patient is reacting to.
  • The patient is unwittingly being exposed to foods which they think they are eliminating due to the large amounts of food additives.
  • Properly tracking symptom reactions each time a food is reintroduced into the diet takes meticulous work, which most patients do not have the time or energy to do.

In summation, the practitioner’s job is to identify foods which is important for their patient to avoid, not to give a nearly impossible job that involves a months long food homework assignment.

Applied Kinesiology Testing

I have been doing kinesiology muscle testing for 13 years now. It can help to uncover food reactions. However, in my experience it is often too sensitive. Testing weak against a food on a muscle test may mean you should never eat the food at all. It may also mean that it wont’ digest well with your last meal and you should not eat it right now. Or perhaps you have been eating too much of something and should not eat it for a week or two.

It is very common for people to test weak against some foods on one visit, and then weak against other foods on another visit.

If a food tests weak repeatedly on every visit, then it becomes more likely that it is a foundation problem that should be avoided all the time.

Ultimately there is just a lot of noise that can come up with muscle testing. It can be a useful tool when used well. But it can not be used to quickly identify a foundational food intolerance.

Carroll Food Intolerance Test

This is a long time used, traditional naturopathic technique for uncovering food intolerance. This is not a food allergy test. So if you have had food allergy testing done in the past, this results are probably different.

I have brought this method into my practice for several reasons:

  • There is a track record of it being used with great results by naturopathic doctors for 90 years.
  • It a way to discover foundational food intolerances.
  • Unlike the muscle testing I also do, the Carroll Food Intolerance Test eliminates much of the noise to uncover the most important foods to eliminate.
  • Helps to identify hidden sources of foods that may be a problem. Many processed foods have additives which can be hidden sources of exposure to offending foods.

Unexplained High Blood Sugar: Is It High Cortisol While You Sleep

Cortisol is very high in the morning. The rest of the day it comes back down to normal.

Unexplained High Blood Sugar: Is It High Cortisol While You Sleep

Cortisol is very high in the morning. The rest of the day it comes back down to normal.
Results from a saliva coritsol test. A spike in cortisol in the middle of the night may cause poor sleep, insomnia dn elevated blood sugar.

What causes high blood sugar?

Most of the time we know what causes high blood sugar. Eating too much food. Especially simple carbohydrates and junk food. But there are other factors which can elevated blood sugar independent of diet.

Other causes of high blood sugar include:

  • Stress and cortisol
  • Nutritional deficiencies

The adrenal glands, cortisol and the stress response

The adrenals are two small glands which sit on top of the kidneys. Their job is to make numerous hormones which regulate stress response including cortisol, epinephrine and aldosterone. For the purpose of keeping things simple, I’m just going to focus on cortisol.

Cortisol is out "Fight or Flight" hormone. Normally it follows a diurnal, rising to it’s highest point in the morning, and then slowly decreasing during the day. Ideally it is lowest at night when we go to sleep.

Chronic stress can deregulate this pattern. Stress is simply the body’s adaptation to any extra demand. This can be psychological stress, or physical stress from an injury. The body's physiological response is the same. The adrenals release cortisol. It’s job is to get more blood and nutrients to the heart, lungs and brain to help you survive an emergency.

Short term elevations of cortisol are essential for survival. But when stress in our daily lives does not go away, cortisol levels get thrown off.

Cortisol may be high, or in some cases the adrenals became exhausted and cortisol is too low. Neither is good. It is also possible for cortisol to be normal for some parts of the day, but deregulated at other times.

Lab tests for blood sugar

Since cortisol raises blood sugar, that means even if you eat a good diet, stress by itself may cause a blood sugar issue. Blood test can help figure this out.

  • Blood glucose: This is your blood sugar levels at any one moment. This test helps diabetics regulate their medications, supplements or diet. A single reading should never be used to determine if someone is a diabetic or has a blood sugar problem. It's possible for blood sugar to be ok during part of the day, and very much off at other times.
  • HgA1c: Used to test blood sugar over time. Hemoglobin is in our red blood cells. Its job is to bind oxygen. Over time blood sugar will glycosylated hemoglobin. The higher the blood sugar over time, the higher HgA1c will be. This test can not be used for short term rises in blood sugar. Instead if shows if blood sugar has been elevated over several months.

Mysteriously high blood sugar and cortisol

If you follow the following pattern, you may be experiencing a spike in cortisol while you sleep, causing high blood sugar:

  • Elevated HgA1c
  • Normal blood glucose levels on blood tests
  • You are not eating a high carbohydrate, or high sugar diet
  • You wake up in the middle of the night for no reason (not all the time, but common)

How to test for middle of the night spikes in blood sugar and cortisol

Go to any drug store and buy a glucometer. I recommend getting a cheap one, as you probably are not going to be using it that often. Take your blood sugar at night and in the morning. If you wake up in the middle of the night, take your blood sugar then as well. It's normal to see some increase in blood sugar as your sleep. This is part of your body getting ready to wake up. However a very large spike can indicate that cortisol is too high. In some people cortisol is normal during most of the day, but goes up way to high at night.

The other test is a saliva cortisol. Theses are commonly used by naturopathic doctors, or other functional medicine practitioners. One of the advantages in using a saliva cortisol tests is that samples can be taken multiple times during the day and even in the middle of the night. If I have a client who is waking up in the middle of the night, I have them take a cortisol sample then, so we can see exactly what is happening.

If blood sugar is spiking in the middle of the night, there is a good chance it is cortisol. The glucometer blood sugar test is therefore a way to infer if cortisol is going up to much at night. The saliva cortisol is a direct measurement.

The advantage to testing blood sugar is you get immediate results. Taking a saliva sample, sending it off to the lab and waiting for results takes about two weeks. You also need to either order a kit from a company that sells it, or get one from a practitioner you are working with. Neither test is that difficult to do, so doing both is really the best option for difficult cases.

How to fix elevated cortisol

The real answer is going to be different for everyone. When working with clients I often use herbs or homeopathics which are best individualized. There are also many different way to lower stress response with lifestyle modifications such as meditation and exercise. Each person needs to find what works for them. In the office I also use a system called Neuro Emotional Technique to help the body release emotional triggers it is holding onto.

Some common supplements for stress, cortisol and blood sugar

These are some supplements that often work. Since everyone is different I can't guanantee these will work for everyone. But, without knowing anything more about a case, other than there is a stress response at night, these are the supplements that come to mind to try first.

  • Seriphos or phosphatidyle serine. Both of these are similiar. Seriphos will actually get converted into phosphatidyle serine in the body. For some people one may work better than the other. Phosphaidyle serine blunts the adrenals from being signaled into making too much cortisol. Doses can vary a lot. My last year in naturopathic school I developed middle of the nigh insomnia. I woke up about 3AM every night, for 8 months in a row. I didn't discover the cause until finally getting a cortisol test from my schools clinic. My cortisol was more than double what it should have been in the morning. One of my teachers told me to try 200 mg of phosphatidyle serine. It did nothing until I took 800 mg before bed.
  • Chromium: this is the most commonly used supplement for elevated blood sugar. Without chromium insulin can not function properly. It's very simply, but does work.
  • Ashwagandah: A very common herb for the adrenals. Some herbs which are used for the adrenals such as rhodiola, American ginseng or licorice can be very stimulating. Ashwagandah is more gentle and over time helps to repair the nervous system. Not a quick fix but generally very good. There are other options, but I can only recommended the bests helps I know if going over a case one one one.

As a side notes, some people may wake up in the middle of the night because cortisol and blood sugar are too low. In those cases eating a snack at night, or taking the herb licorice may help. The herb valarian is also generally for good for sleep. For those those with too much heat (Pitta in Ayurvedic terms) it can actually make their sleep worse. This is why going over a case properly and treating the person is much better than trying various supplements based only on their symptoms or disease.

VedaPulse and Heart Rate Variability

vedapulse electrodes on wrist

VedaPulse and Heart Rate Variability

vedapulse electrodes on wrist

Vedapulse is a tools that measures heart rate variability and converts that information into a functional assessment of the patient’s health. In order to understand how this works some basic concepts about the heart and nervous system need to be understood.

Heart rate is controlled by input from the nervous system. Every second the nervous system senses what is going on through the body and adjust heart rate accordingly. Therefore, a healthy heart rate is one that shows some variability. This is a sign that the nervous system and heart are able to adapt to stress.

Heart rate variability is the difference in time from one heart beat to the next. When healthy it shows some variation in the length of each beat but not so much that it would be considered an an arrhythmia.

The nervous system is divided into two parts:

  1. Somatic nervous system is what we consciously control.
  2. Autonomic nervous system are things which happening automatically, without us thinking. Examples are the heart rate, breathing, digestion and immune system. This is the part of the nervous which Vedapulse can measure.

The autonomic nervous system is further divided into two parts:

  1. Sympathetic nervous system. Stimulates body for intense physical activity. Helps us response to acute stress. The so called "fight or flight" response that we have in emergency situations is controlled by the sympathetic nervous system.
  2. Para-sympathetic nervous system. Opposed the sympathetic nervous system. The phrase "rest and digest," is used to describe it’s actions. It decreases the heart rate, improves digestion and allows the body to repair itself.

Vedapulse works by measuring electrical impulses that come from each heart beat. It shows the pulse wave associated with each heart beat, as well as patterns in heart rate variability from one beat to the next.

Vedapulse heartbeat recording

The following chart shows healthy heart rate variability. The highest bar in the middle show that about half of the heart beats fall into a narrow range of length. Then there are some heartbeats of faster lenght and others which are shorter.

Heart rate variability histogram 1

On the other hand, this chart shows an issue with heart rate variability. About 90% of the heartbeats are all about the same which shows lack of ability for the body to adapt to stress.

vedapulse histogram and low heart rate variability

Further information is gathered by measurement of frequencies of each heartbeat. Without getting into too much unnecessary detail, some frequencies are associated with sympathetic nervous system activity and others with para-sympathetic. This allows Vedapulse to give a lot of information about the state of nervous system health.

All this by itself makes Vedapulse an excellent tool which I would run on almost all clients. But the software is able to go further and convert heart rate variability into a pulse diagnosis according to the methods of Ayurveda and Traditional Chinese Medicine. This gives much more information about the state of each organ system, which ones are depleted or functioning with excess tension.

The following chart shows the Chinese Medicine interpretation.

Vedapulse TCM results

Since adding Vedapulse to my practice I’ve found it to be a helpful tool on most clients. It takes pulse diagnosis from being a subjective interpretation based upon what the practitioner feels, to an objective, measurable diagnosis. Depending upon the client it can be useful in many different ways. Just looking at the heart rate variability aspect can point to issues in cardiovascular system from a conventional perspective.

As an herbalist Vedapulse helps show my clients why I make certain decisions. Traditional herbal medicine is not about matching up the right herbs with specific diseases. It is about choosing the best herbs for the patient. This is based upon concepts such as organ affinity, temperature, and if an herb is exciting or calming.

Vedapulse allows me a way to show clients in an objective way how all of this is affecting their body. It also gives an objective way to follow up later and see what changes have taken place.

Go to the page for more on Traditional Herbal Medicine

Functional Lab Tests For The Digestive System

Functional lab tests help show the root cause of digestive symptoms. These are non-invasive tests that use either stool or saliva samples.

There are several companies offering such testing. This page reviews the tests I have found most helpful with clients.

Diagnostechs GI panel

Diagnostechs GI Health Panel is invaluable for giving clinically relevant information, in a cost effective manner.
The following are the more important markers on their GI Health Panel.

Inflammation

  • Intestinal Lysozyme: marker of colonic inflammation
  • Alpha Anti-chymotrypsin: marker of GI inflammation including in the small intestine
  • Calprotectin: inflammatory marker which can help to differentiate inflammatory bowel disease (Chron’s or Ulcerative Colitis) from other GI system disorders.

Sometimes people have no digestive symptoms, but elevated inflammatory markers. The inflammation may be there and cause other symptoms, such as autoimmune disease or frequent allergies.
However, there are no direct digestive symptoms.
Othertimes, people may have severe GI symptoms, but low inflammatory markers.

Some people have pathogens, or allergies that cause symptoms, but their inflammatory markers are low. You can not assume there is inflammation based upon symptoms alone.

Secretory IgA

Secretory IgA is the immune system’s first line of defense. It is secreted acrross the whole length of the digestive tract.
Its job is to bind to pathogens and alert the rest of the immune system to pathogens.

  • Low total secretory IgA: supressed immunity. Oftern related to stress.
  • Elevated total IgA: increased immune system activity, usually in response to a pathogen.

Specific IgA tests

Besides testing for total IgA levels, it can also be tested against specific foods or pathogens. This helps to show hidden food allergies or parasites.

Available IgA food markers
  • Gliadin (wheat)
  • Corn
  • Soy
  • Egg
  • Cassein (dairy)
IgA tests for parasites

Looking at a stool sample for parasites commonly gives false negative.
Tests for IgA against specific parasites helps to lower the chance of false negatives.
In fact, over years of running this test, I‘ve seen many more times parastites found on IgA tests, then microscopic exam.

  • Blastocystis hominis: estimated 2.6% of US population infected. About 50 to 80% of those infected will present with symptoms, and often diagnosed with “Irritable Bowel Syndrome.”
  • Entamoeba coli: estimated 4.2% of US population infected.
  • Toxoplasma gondi: estimated 40 to 50% of US population infected. Causes multiple symptoms including brain cysts leading to behavioral disorders, muscle cysts, depression, insomnia and reduced stress tolerance.
  • Entamoeba histolytica: causes episodic diarrhea or perianal itch causing colon ulceration. May be locally invasive, causing liver and lung abscesses.
  • Trichinella spiralis: tissue worm, causing abdominal cramping, nausea, diarrhea and muscle soreness and pain leading to fibromyalgia, edema of the upper eye lids or fever.
  • Ascaris lumricoides: roundworm. The most common worm infection in the world. Causes nutritional deficiencies, reduced liver and pancreas function, intestinal colic, diarrhea, dyspepsia and spasmodic cough.
  • H. pylori: common cause of stomach symptoms (they test for this using saliva IgG)

Bacterial and yeast culture

A stool culture for bacteria and yeast can quantify amounts of certain dysbiotic organisms such as candida, Klebsiella, E. coli, Streptococcus and more.

Microscopic Exam

Parasitse may still be found on microscopic exam. For comprehensive testing doing both, looking under the microscope and IgA is best.

FilmArray PCR Gastrointestinal Panel

This is a different lab test avaiable through biofiredx and is more specific for pathogenic bacteria and a few parasites.

PCR stands for polymerase chain reaction. This test looks for strands of DNA to identify specific pathogens. Sometime when there is a need to identify specific pathogens, this is the best way to do it.

The following pathogens can be identified on this test:

BACTERIA:
  • Campylobacter (jejuni, coli, and upsaliensis)
  • Clostridium difficile (toxin A/B)
  • Plesiomonas shigelloides
  • Salmonella
  • Yersinia enterocolitica
  • Vibrio (parahaemolyticus, vulnificus, and cholerae)
  • Vibrio cholerae
DIARRHEAGENIC E. COLI/SHIGELLA
  • Enteroaggregative E. coli (EAEC)
  • Enteropathogenic E. coli (EPEC)
  • Enterotoxigenic E. coli (ETEC) lt/st
  • Shiga-like toxin-producing E. coli (STEC) stx1/stx2
  • E. coli O157
  • Shigella/Enteroinvasive E. coli (EIEC)
PARASITES:
  • Cryptosporidium
  • Cyclospora cayetanensis
  • Entamoeba histolytica
  • Giardia lamblia
VIRUSES:
  • Adenovirus F40/41
  • Astrovirus
  • Norovirus GI/GII
  • Rotavirus A
  • Sapovirus (I, II, IV, and V)

Who may benefit from a functional digestive system test?

Since digestion effects just about every other part of the body, there are many conditions where functional tests for the digestive symptoms may be helpful. The following are a few of the most common examples:

  • Anyone with chronic digestive issues such as cramps, bloating, chronic constipation or diarrhea, IBD, IBS
  • Conditions of inflammation such as autoimmune disease, sleep apnea, or multiple food allergies
  • Unexplained fatigue
  • Chronic Candida or other yeast infection that does not easily resolve

Heavy Metals And Toxicity Lab Tests

Naturopathic medicine and lab tests for toxicity

As a naturopathic doctor people come in to see me for a wide range of issues. This includes fatigue, autoimmunity, various hormonal issues, skin rashes, acne, chronic Candida, digestive issues and mental symptoms. All of these (and more) may be related to toxcity. 

Some ways toxicity impairs health:

  • Blocks the production of energy at the cellular level. This causes fatigue.
  • Heavy metals such as lead and mercury are neurotoxins. They kill nerve cells. These metals effect memory, cognition and may contribute to depression and anxiety.
  • Toxicity is associated with autoimmune disease.
  • Many toxins are carcinogenic (they cause cancer).
  • BPA (bisphenol A) and other environmental toxins mimic estrogen. This leads to hormonal issues in women and men.
  • Toxins change the environment within the body making it more susceptible to Candida, yeast and other infections.

Toxicity is a problem that can contribute to virtually any symptom a client comes in with. This is why, as a naturopathic doctor I test. I want to figure out what the cause of my client’s symptoms are.

This page is primarily about how to test for heavy metals. For more general information on environmental toxicity I suggest going to the Environmental Working Group page.

Blood Tests For Heavy Metals

Blood tests are good for very recent exposures. For example blood levels of lead show if children are actually exposed.

However, blood tests for heavy metals have a limited use. The body does not keep toxins in circulation for long. Metals are either excreted from the body, or end up stored inside of tissue. Just because a  blood tests says your levels of heavy metals are fine, that doesn’t mean it’s not lurking inside organs such as the kidneys or the brain.

Blood tests can give patients a false sense of security. They may be told they are fine because it’s not on the blood tests. But, not in your blood doesn’t mean not in your body. This is why it’s important to work with someone who is trained in how to test for environmental toxicity.

Functional Lab Tests For Toxicity

The following reviews four different lab tests I use at times for toxicity. All of them are from the company Doctors Data. You may go to their website for even more information.

Hair Analysis

Hair analysis is a good tests for heavy metals. However, it needs to be interpreted by someone trained to do so. Sometimes ratios between minerals matter. Other times patterns may show hidden toxicity that is apparent when first looking at results.

The following example should show how hair analysis is helpful, and why proper interpretation is essential.

 

Hair test 1: pre-detoxification

The initial test was done on the onset of detoxification. The bottom part that covers “Essential and Other Elements” is looked at first. Without looking at specific values of individual elements, it should be clear that almost all of them are under the 50th percentile. This is one of several patterns of mineral deregulation due to toxicity. In this case the proper treatment was to work on detoxification in general, rather than trying to manipulate levels of any one particular mineral.

The toxic metal section did show very high amounts of mercury and silver. However, considering the degree of mineral deregulation seen in the bottom portion, it would be wrong to assume that this was the the extent of her metal toxicity.

 

Hair analysis test results. Low lead and high mercury.

Hair test 2: during detoxification

The protocol included a custom formulated herbal tincture, some vitamins, a chlorphylin supplement and low potency compound homeopathics to help stimulate metal detoxification. The specific supplements are not being listed, as they were meant for her alone based upon the overall assessment. Other people following her protocol would not have the same results.

Client experienced significant improvement of symptoms. Mostly notably reduction in those related to chronic yeast infection. Previously extensive dietary changes and supplementation with herbs to kill yeast has only mild effect.

The “essential and other elements” portion also no longer showed such a deregulated pattern (although it was far from perfect and indicated the further detoxification is still needed).

 
Lead detoxification and other metals from detoxification program.

Urinary Porphyrin Test

Urinary porphyrins are metabolites produced in the production of hemoglobin. They may have long and complicated names, but they are just by-products of red blood cell formation.

What’s important is that different toxins can interfere in how these metabolites function, causing them to spill out into the urine. A urinary porphryin test is thus an indirectly assessment of the burden of toxicity on the body.

Unlike other tests which only look at metals, a porphryin tests also helps to evaluate other toxins: Hexachlorobenzene, dioxin, methylchloride, PVC and PBA.

The advantages of a porphyrin tests is that it’s easy to do (a simple morning urine collection), and it is more broad than a hair analysis which only looks at metals.

The disadvantage is that results are not as specific. For example an elevated coproporphyrin III may indicate lead, or PBA. Sometimes I like to combine both tests for a more complete view.

Results from Doctors Data Urinary Porphyrin test

Stool and Urine Metal Tests

Urine tests for metals only measure what is spilling out into the urine. Unless you are taking a chelating agent such as DMSA (which will detoxify mercury through the kidneys), then it’s unlikely to see much on these test. metals.
 
For a long time urine metals tests where popular. This is because they where given with DMSA. Over 10 years ago the FDA took DMSA off the market and now it is only available as prescription.
 
There are plenty of other natural metal chelators available. However, these will use the body’s more natural detoxification routes and move most metals out through the liver. Metals will then be excreted in stool.  Therefore, if there is a need to test how much detoxification is happening in the moment, a stool metal test may be the best option.
 
Doctors Data has both urine metal and fecal metal tests available.