Androgen Testing For Women and PCOS<

Flow chart of androgens. DHEA to androstedione to testosterone and finally dht. Testosterone may also be convereted into estrogen
Flow chart of androgens. DHEA to androstedione to testosterone and finally dht. Testosterone may also be convereted into estrogen
Androgen Hormone Pathyway

Androgens are hormones which are normally higher in men, than women. However in some conditions they may too high in women causing symptoms. Mostly commonly this happens in PCOS (poly-cystic ovarian syndrome).

Common symptoms of too high androgens in women

  • Hirsutism (facial hair)
  • Acne. Often hormonal acne around the chin
  • Hair loss

The four androgens are:

  • DHEA
  • Androstedione
  • Testosterone
  • DHT

Along with pregnenolone, cortisol, progesterone, and the estrogens, these make up the steroid hormones.

Testing Androgens

In a case of PCOS testing androgens is very important. First this can verify if androgens are elevated. It can also help to identify which type of PCOS is present. Finally, it gives markers which allow for progress to be tracked.

There are 4 general types of PCOS:

  • Insulin resistant
  • Post Pill
  • Inflammatory
  • Adrenal

A good hormone test can help diagnose which type. Is the problem insulin? Then you want to test insulin levels. In an andrenal pattern of PCOS, only DHEA will be elevated. The other androgens are normal.

Blood or saliva hormone tests

Hormones can be tested in either blood or saliva. Most patients will have a blood test. Advantages with blood tests are that it can run along with other basic blood work. It is more commonly accepted by insurance.

There are also problems with blood tests. Often patient have incomplete labs with only DHEA and testosterone. The other problem I see are false negatives. Numerous times I have seen women with elevated saliva androgens who have normal looking blood work.

Unlike blood tests, saliva is a marker of cellular hormone levels. It does a better job at showing how much hormone your cells have, not just what is circulating in blood at the moment. Saliva hormone tests will cover all the androgens. Other hormones such as insulin and cortisol can also be tested in saliva, allowing for full testing of all the hormone involved in PCOS.

Blood sugar and PCOS

Elevated blood sugar and insulin resistanc is a common cause of PCOS. But this is not always the culprit. Testing insulin is a way to tell if this needs to be addressed or not.

Saliva test for insulin. Before and after eating.

Cortisol and stress

Cortisol is our major stress hormone. High cortisol can raise blood sugar and DHEA. In some cases it can be helpful to test cortisol as well to see if stress response is contributing to symptoms.

Cortisol tested 4 times as part of the ASI (adrenal stress index) test.

Conventional versus naturopathic protocols

Conventional doctor will treat high androgens with medications. Often this is metformin for high blood sugar, or androgens blockers spironolactone, or cyproterone acetate. Naturopathic medicine on the other hand seeks to identify what the cause of elevated androgens is, and treat that with diet, lifestyle and more gentle herbs or other supplements.

Naturopathic Treatment of PCOS

What is PCOS?

Polycystic Ovarian Syndrome (PCOS) may be diagnosed when two of the following symptoms are present:
  • Irregular menstrual cycle
  • Elevated androgens (the hormones DHEA, testosterone, androstenedione and DHT)
  • Polycystic ovaries (seen on ultrasound)
It is common for the diagnosis to be based upon an ultrasound. This is not enough. PCOS is not the only cause of ovarian cysts.

Conventional treatment

Common medications for PCOS include:
  • Metformin for blood sugar control
  • Medications for elevated cholesterol and lipids
  • Birth control pills to “regulate” the cycle
  • Medication for excess androgens (Spironolactone)

What causes PCOS?

Conventionally there is no single known cause. PCOS is not one thing. It is a set of symptoms which commonly happen together for various reasons. However, we know of many contributory factors. These includes:
  • Insulin resistance
  • Body weight
  • Stress
  • Withdrawal from birth control pills
  • Poor nutrition
  • Environmental toxicity.
Each time I start with a complete history individualized assessment and treat the client (not the disease). I do not wish to box everyone into a few categories. What I list below are simply the more common factors causing PCOS. Since PCOS is a syndrome and not a distinct disease, this may not apply to everyone.

Elevated blood sugar and insulin resistance

High blood sugar is a well-known trigger for PCOS. In natural health we know how to treat this as it’s a condition of lifestyle and diet. Often I see people who have blood sugar issues despite eating a good, low-carb diet. This is frustrating. Doctors tell women to balance blood sugar, they do, and then still have PCOS. Elevated blood sugar and insulin reistance is not always a factor. In these situations I look for other factors that raise blood sugar. These include:
  • Specific nutritional deficiencies
  • Other endocrine issues (thyroid, adrenals)
  • Liver function and underlining toxicity

Chronic inflammation

The most common lab tests for inflammation includes:
  • CBC with differential
  • ESR (SED rate)
  • C-reactive protein
There are many possible causes of inflammation. Some causes are a poor diet, infection, and toxicity.

Androgen Excess

This is a shift in hormone production towards testosterone and the other “male hormones.” Typical symptoms seen with this include hair loss (on head) hair growth (on face) acne and oily skin. Conventional treatment is often the prescription of spironolactone. Natural considerations are to work on:
  • Stress and adrenal function
  • Nutritional deficiencies
  • Liver and detoxification. Many environmental toxins act like estrogen in the body and contribute to PCOS. BPA is a well known example of this.  [1]

Lack of ovulation after getting off the pill

Sometime the endocrine system needs time to adjust after being on birth control pills. Herbal medicine and good nutrition can help women to get their cycle to normal.

Other causes of PCOS

The above causes do not apply to everyone. Like any other condition I start with a review of symptoms, case history, in office evaluation and then consider lab tests. This may mean testing hormones. But it often means looking at other systems such as digestion, adrenal, thyroid, immune system, or specialized labs for toxicity.

Additional Resources

Testing.com has good information on lab tests for female hormones from a functional perspective

Reference

[1] https://www.ncbi.nlm.nih.gov/pubmed/21193545

Naturopathic Treatment of PMS and PMDD

This is just a short list of common PMS symptoms:

  • Decreased energy
  • Irritability and anger
  • Food cravings
  • Depression or anxiety
  • Headache
  • Low sex drive
  • Breast pain
  • Muscle aces
  • Acne
  • Abdominal bloating

Conventional treatment is birth control pills. When PMS is very bad, it is called PMDD. This may even be treated with psychiatric medication. These treatment options do not treat the actual cause of symptoms.

It is absurd that women are given these two choices. Either suppress symptoms, or suffer. Natural health gives another option, to know what is causing these symptoms and to fix the problem.

Causes of PMS and PMDD

In natural health we can understand what causes symptoms and treat it. Below I review the most common reasons women get PMS symptoms. Ideally, it is best to work with a natural health care practitioner who can review your case and do tests to figure out the specific cause of your symptoms.

Toxicity, the liver and estrogen

Many symptoms of PMS are due to estrogen excess. Estrogen may not be elevated during the whole cycle. Fluctuations during short periods of the cycle can cause symptoms.

Symptoms of estrogen excess:

  • Bloating
  • Water retention
  • Very heavy bleeding
  • Cramps
  • Breast pain

The ovaries make estrogen, then the liver breaks it down and detoxifies it. If the liver is sluggish, then estrogen builds up causing symptoms. Therefore, the liver may need support to treat PMS.

From a certain point of heavy bleeding and cramps comes from the body trying to protect itself. If we have too many toxins for the liver to process, the body uses other methods of detoxification. The period gives women and an excellent auxiliary route of elimination. They can bleed toxins out. The naturopathic treatment is thus to aid the body, so it no longer needs to do this.

Why see a Naturopathic doctor for detoxification?

There are many supplements that aid the liver in detoxification and help PMS. Common examples are DIM, NAC and milk thistle. So why not just take those supplements? What’s the point in seeing someone?

When working with clients I do not simply hand out general advice. If working on detoxification anything I do will be based upon the totality of my clients symptoms, along with in office evaluation and lab tests to created a plan specific for them.

Digestion and gut dysbiosis

Gut dysbiosis refers to the balance of bacteria, yeast and other microbes in the digestive tract.

After the liver detoxifies estrogen it’s still not out of your body. It has to travel through the digestive system and is eventually excreted in the stool.

Some bacteria in the gut make and an enzyme called beta-glucuronidase. This causes the absorption of estrogen back into the body. Thus, working on gut health, diet, and possibly taking probiotics is part of treating PMS.

There are other ways dysbiosis can contribute to PMS. Yeasts such as Candida release toxins which put an extra burden on liver detoxification. Fermentation of foods in the upper GI system (caused by SIBO) also put extra stress on the liver and cause other symptoms such as brain fog and fatigue.

Plastics and xeno-estrogens

It is not just the estrogen that your body makes that needs to be eliminated. Over the past few decades our society has become bombarded with environmental toxins that mimic estrogen. The most well known of these is BPA (bisphenol A). Industrial toxins that act like estrogen in the body are called “xeno-estrogens.”

Other estrogen mimicking toxins:

  • The pesticides DDT and DDE
  • Polychlorinated biphenyl (PCB)
  • Polychlorinated phenols (PCP)
  • Dieldrin
  • Chlordane

It’s hard for the body to break down these chemicals. Over time they become stored in fat cells. Learning how to avoid these toxins and taking steps to eliminate those we have exposed to is essential
for good hormonal health.

Some people may think that taking supplements and doing extra things for detoxification isn’t natural. They say all we need is a “good diet.” Maybe that was true 200 years ago. The way it is now, we are not living in a naturally world. We are surrounded with synthetic chemicals and our bodies need help to get rid of them.

Hypothyroidism

Low thyroid hormone slows down your whole body. It can also make PMS worse. Hypothyroidism often goes undiagnosed. There are numerous causes from hypothyroidism. Three of the more common causes are:

  • Autoimmune thyroiditis (Hashimoto’s disease)
  • Secondary to other illness, such as infection or adrenal fatigue
  • Nutritional deficiencies

I have other pages on hypothyroidism. Going into detail here is beyond the scope of this article. However, one nutrients I use often and is essential to women’s health is iodine.

Iodine is used to make thyroid hormone. It’s also essential for the ovaries and breast tissue. This is why women often need it much more than men. I believe many women’s health issues can be prevented or helped by using iodine.

Cortisol and Stress

Emotional stress causes an increase in the adrenal hormone cortisol. Cortisol raises blood sugar, blood pressure and helps us get through moments of stress.

If the stress remains, cortisol stays elevated. This leads to fatigue, blood sugar disorders and has numerous affects on other hormones. One of these is to lower progesterone. Progesterone deficiency is another cause for PMS symptoms.

Nutritional deficiencies

Nutrients which are commonly deficient in PMS include

  • B vitamins, especially B6
  • Magnesium
  • Essential fatty acids. This could be a need for fish oil, but some people actually need other oils. Evening primrose and borage oil help many women. Fish oil is needed in high doses for people who eat the “Standard American Diet.” My clients are generally much more health conscious than the average American, and thus do not need high dose fish oil to make up for a diet high in poor quality fats.
  • Zinc
  • Vitamin E
  • Iodine
I utilized several different methods for assessing such deficiencies. This includes careful review of symptoms, in person examination, kinesiology testing and directly testing for nutrients on lab tests.

Treating PMS

There are many options. But like any symptoms I always start by evaluating the whole person. Treat the person. Don’t treat PMS. PMS (even if you have severe symptoms) can see great improvement with natural health.

Lab tests

Female hormones can be tested in two ways:

  • Blood tests
  • Saliva hormone tests

Both of these have their advantages. Saliva is more accurate measurement of how much hormone is inside our cells. Multiple samples aer also easy to take, so it’s possible for a women to take samples during her whole period and chart out estrogen, progesterone, LH and FSH on a lab test.

Disadvantages with saliva testing is that it can take weeks to get test results back. It is also not covered by insurance.

You can read more about saliva testing for female hormones on this page

With blood tests the turn around time for results in much quicker. Insurance coverage is much easier to have as well.

How interested I am in lab tests depends on the case. I generally want labs in cases with severe symptoms, someone who wants to get pregnant, PCOS or symptoms of high androgens. Most cases of PMS can be helped greatly by working on the factors I listed on this page. Functional labs for toxicity such as hair analysis, or testing nutrient levels may be more helpful at fixing the cause than working directly off of hormone levels.

Herbal medicine

Herbs are best prescribed based upon a constitutional assessment. The herbs are given for the person, not the disease. There are herbs very commonly used for PMS such as black cohosh or chaste berry. Sometimes it’s the less well known herbs that work best.

As an herbalist I keep about 200 different herbs on hand in my office and often mix customized formulas.

Go to the page on herbal medicine for more information

Additional Resources

Testing.com has good information on lab tests for female hormones from a functional perspective